^ Blum K, Werner T, Carnes S, Carnes P, Bowirrat A, Giordano J, Oscar-Berman M, Gold M (2012). "Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphisms". Journal of Psychoactive Drugs. 44 (1): 38–55. doi:10.1080/02791072.2012.662112. PMC 4040958. PMID 22641964. It has been found that deltaFosB gene in the NAc is critical for reinforcing effects of sexual reward. Pitchers and colleagues (2010) reported that sexual experience was shown to cause DeltaFosB accumulation in several limbic brain regions including the NAc, medial pre-frontal cortex, VTA, caudate, and putamen, but not the medial preoptic nucleus. Next, the induction of c-Fos, a downstream (repressed) target of DeltaFosB, was measured in sexually experienced and naive animals. The number of mating-induced c-Fos-IR cells was significantly decreased in sexually experienced animals compared to sexually naive controls. Finally, DeltaFosB levels and its activity in the NAc were manipulated using viral-mediated gene transfer to study its potential role in mediating sexual experience and experience-induced facilitation of sexual performance. Animals with DeltaFosB overexpression displayed enhanced facilitation of sexual performance with sexual experience relative to controls. In contrast, the expression of DeltaJunD, a dominant-negative binding partner of DeltaFosB, attenuated sexual experience-induced facilitation of sexual performance, and stunted long-term maintenance of facilitation compared to DeltaFosB overexpressing group. Together, these findings support a critical role for DeltaFosB expression in the NAc in the reinforcing effects of sexual behavior and sexual experience-induced facilitation of sexual performance. ... both drug addiction and sexual addiction represent pathological forms of neuroplasticity along with the emergence of aberrant behaviors involving a cascade of neurochemical changes mainly in the brain's rewarding circuitry.
UKAT have already treated over 1,000 people with alcohol addiction in our private residential rehabilitation centres this year, the vast majority of which had to be medically supported during their initial detoxification stage. Going 'cold turkey' from alcohol is extremely dangerous; the individual could experience seizures, hallucinations, sweating, anxiety, depression, tremors and nausea.( Eytan Alexander 2 Oct 2018 )
Substance abuse therapy: Used as a part of many inpatient and outpatient programs, therapy is one of the cornerstones of drug addiction treatment. Individual, group and family therapy help patients and their loved ones understand the nature and causes of addiction. Therapy teaches coping strategies and life skills needed to live a productive, sober life in the community. For individuals with a co-occurring mental illness, intensive psychotherapy can also address psychiatric symptoms and find the underlying issues that contribute to addiction. Inside Shalom House, Australia’s ‘strictest’ drug rehabilitation | Australian Story