contribute to mental illness including depression and anxietycause significant liver damage, ultimately preventing the liver from functioningcontribute to developing one of several different kinds of cancerincrease your chances of developing heart diseaseincrease your chances of using other drugscontribute to developing chronic hypertensionlead to the loss of your job and, as a result, financial instabilitydo irreparable harm to your marriage/family relationshipslead you to a life controlled by addictionlead you to a life of crime as you seek to support your addiction.
^ Nestler EJ (August 2016). "Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function"". Brain Research. 1645: 71–4. doi:10.1016/j.brainres.2015.12.039. PMC 4927417. PMID 26740398. These findings led us to hypothesize that a concerted upregulation of the cAMP pathway is a general mechanism of opiate tolerance and dependence. ... We thus extended our hypothesis to suggest that, particularly within brain reward regions such as NAc, cAMP pathway upregulation represents a common mechanism of reward tolerance and dependence shared by several classes of drugs of abuse. Research since that time, by many laboratories, has provided substantial support for these hypotheses. Specifically, opiates in several CNS regions including NAc, and cocaine more selectively in NAc induce expression of certain adenylyl cyclase isoforms and PKA subunits via the transcription factor, CREB, and these transcriptional adaptations serve a homeostatic function to oppose drug action. In certain brain regions, such as locus coeruleus, these adaptations mediate aspects of physical opiate dependence and withdrawal, whereas in NAc they mediate reward tolerance and dependence that drives increased drug self-administration.
Heroin is a semi-synthetic opiate that was first developed from morphine in 1874. At the end of the 19th century, heroin was produced on a commercial basis as a possible solution to the growing problem of morphine addiction. However, it soon became apparent that heroin itself was highly addictive. In 1924, the Heroin Act made it illegal to produce, import, or possess heroin in the US. Heroin is now illegally imported from Asia, South America, and Mexico. With the rise in prescription opioid abuse, heroin has also become more popular. According to the New England Journal of Medicine, the introduction of a form of OxyContin designed to deter abuse has led to a corresponding spike in heroin abuse, as opioid addicts turn to this street drug to get the same euphoric high.
The National Institute on Drug Abuse (NIDA) established that benzodiazepines have a short half-life, causing abusers to develop a quick and dangerous tolerance – often in as little as six weeks.3 Once a person becomes addicted, the drug causes rebound symptoms of the disorder it was originally prescribed for. Weaning off benzos is a very long and detailed process.
An individual who suffers from both mental illness and alcoholism will need to undergo different treatment. Because alcohol withdrawal symptoms cause a person to experience some psychiatric stress, an alcoholic with mental health issues will find it much more difficult to resist turning to drink. The NIAAA believes the some self-help groups, such as Alcoholics Anonymous, are not effective when it comes to treating people with a dual-diagnosis of both alcoholism and mental illness. This is because these groups tend to specifically focus on the actual addiction itself, rather than any underlying psychological problems. Anti-depressants are improving all the time and it is believed that while a self-help group may not be useful for a dual-diagnosis individual by itself, if the individual is on the appropriate medication and receiving the appropriate psychological therapy it can prove to be just as effective as with other alcoholic individuals.

The National Institute on Drug Abuse (NIDA) established that benzodiazepines have a short half-life, causing abusers to develop a quick and dangerous tolerance – often in as little as six weeks.3 Once a person becomes addicted, the drug causes rebound symptoms of the disorder it was originally prescribed for. Weaning off benzos is a very long and detailed process.
A detoxification rehab program stipulates that before patients can begin healing, they must remove all drugs and toxins from their body. It is much easier to detox from drugs under the care and supervision of trained medical professionals, as opposed to attempting to do it on your own. Medical professionals could provide patients with safe drugs that could help ease withdrawal symptoms.
Some addicts may require a detoxification cycle before beginning addiction treatment. This is perhaps one of the most significant misconceptions of drug rehab. Many people assume that detoxification is standard practice and is the “only” thing that occurs in a rehabilitation clinic. However, this is not the case. Drug rehab clinics seek to address the root problem to help break the long-term cycle of addiction.
This is an ongoing debate in the medical community, but it is generally agreed that there is no one cause for the development of addiction. According to the National Institute on Drug Abuse, contributing factors may include a genetic predisposition to develop addictive tendencies, an environment that is permissive of drug abuse, access to illicit substances, and certain developmental issues. The existence of a Dual Diagnosis is one of the biggest risk factors for the development of addiction. Heroin Withdrawal | First Week In
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